Article

Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation

2025-01-18

Abstract excerpt

<h4>Rationale</h4> WW domain-containing oxidoreductase ( WWOX ) is a gene associated implicated in both neurologic and inflammatory diseases and is susceptible to environmental stressors. We hypothesize partial loss of Wwox function will result in increased sepsis severity and neuroinflammation. <h4>Methods</h4> Wwox WT/P47T mice, generated by CRISPR/Cas9, and Wwox WT/WT mice were treated with intraperitone...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0abb6252-16af-5eb3-a223-329e9d80485d
DOI: 10.1101/2025.01.17.633677

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Partial Wwox Loss of Function Increases Severity of Murine Sepsis and NeuroinflammationDOI 10.1101/2025.01.17.633677Read

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic InflammationSemantic proximity Read

A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young miceSemantic proximity Read

A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomesSemantic proximity Read

Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsisSemantic proximity Read

WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12Semantic proximity Read

Exploiting the Zebrafish Model for Sepsis Research: Insights into Pathophysiology and Therapeutic PotentialsSemantic proximity Read

WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12.Semantic proximity Read

mRNA and long non-coding RNA expression profiles in rats reveal inflammatory features in sepsis-associated encephalopathySemantic proximity Read

Hv1 proton channel is essential for splenic antibacterial defense and immune homeostasis during the chronic phase of traumatic brain injury in male miceSemantic proximity Read

Protective Role of Cytochrome P450 Oxidoreductase in Sepsis Development: Genetic and Phenotypic Analyses.Semantic proximity Read

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity Read

Infection and chronic disease activate a systemic brain-muscle signaling axisSemantic proximity Read