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Article

Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.

Molecular systems biology - 22 Nov 2011

Aldridge Bree B, Gaudet Suzanne, Lauffenburger Douglas A, Sorger Peter K

Abstract excerpt

Receptor-mediated apoptosis proceeds via two pathways: one requiring only a cascade of initiator and effector caspases (type I behavior) and the second requiring an initiator-effector caspase cascade and mitochondrial outer membrane permeabilization (type II behavior). Here, we investigate factors controlling type I versus II phenotypes by performing Lyapunov exponent analysis of an ODE-based model of cell death....

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Source

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Identifiers

PMID: 22108795
DOI: 10.1038/msb.2011.85
PMCID: PMC3261706

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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