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Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injury

2006-10-01

Abstract excerpt

Background: Smad2 and Smad3 are transcription factors that mediate transforming growth factor beta (TGF-β) signals. Upon their activation, phosphorylated Smad2/Smad3 (pSmad2/Smad3), translocate to the nucleus and associate with co-activators such as p300, regulating the transcription of genes that contribute to the fibrotic processes. Methods: We investigated the immunohistochemical expression of pSmad2/Smad3 and...

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Identifiers and source

Literature Corpus work
f1efe52d-23c6-500f-9cca-cb4681968d4f
DOI
10.2755/jcmm010.004.05
PMCID
PMC3933079
Open publication

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Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injuryDOI 10.2755/jcmm010.004.05
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