Killing by Proximity

Abstract excerpt

p53 tumor suppressor evolved as the critical player in navigating the response to environmental stresses such as DNA, or oxidative damage and drives the cell fate by governing the live and death decision. The p53 protein is encoded by the most commonly mutated gene in human cancers. TP53 gene mutations are associate with worse prognosis and refractory and relapse disease. The most prevalent mutations are of the mi...

Topics

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• Antineoplastic Agents
• Apoptosis
• Cell Cycle Proteins
• Mutation
• Mutation, Missense
• Neoplasms
• Proto-Oncogene Proteins c-mdm2
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

f1ecc4fa-2a31-56ed-a29c-ca96423a73f7

DOI

10.20944/preprints202512.0180.v1