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Article

Harnessing p53 for Proximity Killing.

International journal of molecular sciences - 25 Jun 2026

Zawacka Joanna E

Abstract excerpt

p53 tumor suppressor evolved as a critical player in navigating the response to environmental stresses such as DNA or oxidative damage and drives cell fate by governing life and death decisions. The p53 protein is encoded by the most commonly mutated gene in human cancers. TP53 gene mutations are associated with worse prognosis and refractory and relapsed disease. The most prevalent mutations are of the missense...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42449998
DOI: 10.3390/ijms27135725
PMCID: PMC13362038

Genes

TP53
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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