RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver Infection

Abstract excerpt

The LS of Plasmodium infection is an asymptomatic yet necessary stage for producing blood-infective parasites, the causative agents of malaria. Blocking the liver stage of the life cycle can prevent clinical malaria, but relatively less is known about the parasite’s biology at this stage. Using the rodent model P. berghei , we investigated whole-transcriptome changes occurring as early as 2 hpi of hepatocytes....

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