Article

Spatial second-order features predict glioma malignant transformation

2026-08-17

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutant gliomas often transform from low to high grade aggressive tumors. The genetic and molecular drivers of this Malignant Transformation (MT) are poorly understood, and predicting whether a patient will undergo MT is an unmet challenge of high clinical relevance. To stratify patients by MT risk, we applied integrated spatial DNA and RNA profiling to biopsies from 18 retrospective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1d8ccea-4062-5df5-9100-a8db2c929425
DOI: 10.64898/2026.08.14.744974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial second-order features predict glioma malignant transformationDOI 10.64898/2026.08.14.744974Read

Multi-omics integrative analysis of the glioma microenvironment reveals IDH-dependent cellular communication and prognostic signaturesSemantic proximity Read

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastomaSemantic proximity Read

spARC recovers human glioma spatial signaling networks with graph filteringSemantic proximity Read

Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk modelSemantic proximity Read

AAnet resolves a continuum of spatially-localized cell states to unveil tumor complexitySemantic proximity Read

A map of tumor–host interactions in glioma at single-cell resolutionSemantic proximity Read

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside gliomaSemantic proximity Read

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironmentSemantic proximity Read

Decoding Multicellular Communication Motifs from Spatial Transcriptomics with ALARMISTSemantic proximity Read

Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME.Semantic proximity Read

Glioma progression is shaped by genetic evolution and microenvironment interactions.Semantic proximity Read

Algorithmic Reconstruction of GBM Network ComplexitySemantic proximity Read