CRISPR interference at the <i>FAAH-OUT</i> genomic region reduces <i>FAAH</i> expression

Abstract excerpt

FAAH-OUT encodes a putative long non-coding RNA which is located next to the FAAH gene on human chromosome 1. Recently an ~8 kb microdeletion, that removes upstream regulatory elements and the first 2 exons of FAAH-OUT , was reported in a pain insensitive patient (PFS) with additional clinical symptoms including a happy, non-anxious disposition, fast wound healing, fear and memory deficits, and significant post-...

Topics

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• Autophagy in Disease and Therapy
• Cannabis and Cannabinoid Research
• Gene Expression Regulation
• Genome-Wide Association Study
• Pain
• Pancreatic function and diabetes
• Polymorphism, Single Nucleotide
• RNA, Long Noncoding

Identifiers and source

Literature Corpus work

f1ceef61-f959-5d68-82f5-e63297fc1a4b

DOI

10.1101/633396