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Article

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome.

Scientific reports - 13 Sept 2018

Skakkebæk Anne, Nielsen Morten Muhlig, Trolle Christian, Vang Søren, Hornshøj Henrik, Hedegaard Jakob, Wallentin Mikkel, Bojesen Anders, Hertz Jens Michael, Fedder Jens, Østergaard John Rosendahl, Pedersen Jakob Skou, Gravholt Claus Højbjerg

Abstract excerpt

Klinefelter syndrome (KS) has a prevalence ranging from 85 to 250 per 100.000 newborn boys making it the most frequent sex chromosome aneuploidy in the general population. The molecular basis for the phenotypic traits and morbidity in KS are not clarified. We performed genome-wide DNA methylation profiling of leucocytes from peripheral blood samples from 67 KS patients, 67 male controls and 33 female controls, in...

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Share to Chromosomes, Human, X
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Infant, Newborn

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Source

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Identifiers

PMID: 30213969
DOI: 10.1038/s41598-018-31780-0
PMCID: PMC6137224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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