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Article

Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance.

Molecular pharmaceutics - 4 Aug 2014

Roy Aniruddha, Murakami Mami, Ernsting Mark J, Hoang Bryan, Undzys Elijus, Li Shyh-Dar

Abstract excerpt

Taxanes are a class of anticancer agents with a broad spectrum and have been widely used to treat a variety of cancer. However, its long-term use has been hampered by accumulating toxicity and development of drug resistance. The most extensively reported mechanism of resistance is the overexpression of P-glycoprotein (Pgp). We have developed a PEGylated carboxymethylcellulose conjugate of docetaxel (Cellax),...

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Identifiers

PMID: 24564177
DOI: 10.1021/mp400643p
PMCID: PMC4122598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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