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Article

Enhancement of the loss of multiple drug resistance by hydroxyurea.

Seminars in oncology - 1 Jun 1992

Christen R D, Shalinsky D R, Howell S B

Abstract excerpt

Gene amplification is one mechanism whereby tumor cells can become resistant to antineoplastic agents. Unstably amplified genes occur either on submicroscopic circular pieces of extrachromosomal DNA called episomes or on small acentric chromosomes called double minutes. Double minutes are frequently associated with cells containing amplified drug-resistance genes. Human epidermoid carcinoma KBV1 cells contain...

Topics

Carcinoma, Squamous Cell
Cisplatin
Dose-Response Relationship, Drug
Drug Resistance
Gene Amplification
Humans
Hydroxyurea
Neoplasm Proteins
Phenotype
Tritium
Tumor Cells, Cultured
Vinblastine

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PMID: 1641661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1641661-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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