Article

Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex

2023-05-26

Abstract excerpt

The mammalian tRNA ligase complex (tRNA-LC) catalyzes the splicing of intron-containing pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein response (UPR) in the cytoplasm. We recently reported that the tRNA-LC co-evolved with PYROXD1, an essential oxidoreductase that protects the catalytic cysteine of RTCB, the catalytic subunit of the tRNA-LC, against aerobic oxidation. In this st...

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Identifiers and source

Literature Corpus work: 96741064-70b1-58ae-aaf4-4440356b6781
DOI: 10.1101/2023.05.26.542437

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