Article
Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets.
Vaccine - 17 Jan 2011
Yang PengHui, Duan YueQiang, Wang Cheng, Xing Li, Gao Xiao, Tang Chong, Luo DeYan, Zhao ZhongPeng, Jia Weihong, Peng Daxin, Liu Xiufan, Wang Xiliang
Abstract excerpt
A novel 2009 influenza A (H1N1) virus was transmitted from humans to humans worldwide. The live attenuated monovalent A H1N1 vaccine (LAMV) for intranasal administration has shown promising immunogenicity and safety in clinical trials and for human use, but the experimental data based on LAMV is incomplete. In this study, using reverse genetic technology, we produced a cold-adapted (ca), live attenuated BJ/AA ca...
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