Multi-scale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts

Abstract excerpt

<h4>ABSTRACT</h4> Aging is closely associated with cardiovascular diseases, the leading cause of mortality worldwide. Mitochondrial dysfunction is a hallmark of cardiovascular aging because it generates most of the heart’s ATP at the cristae, specialized sub-compartments where OXPHOS takes place. In this study, we used multiple-scale electron microscopy approaches to evaluate age-related mitochondrial and cristae...

Topics

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• Desmoglein 2
• Adipose Tissue and Metabolism
• Arrhythmogenic Right Ventricular Dysplasia
• Autophagy in Disease and Therapy
• Disease Models, Animal
• Metabolomics and Mass Spectrometry Studies
• Mice, Inbred C57BL
• Mitochondrial Function and Pathology

Identifiers and source

Literature Corpus work

f1783961-6fbc-577e-9a46-88dc6c64f16a

DOI

10.1101/2025.04.01.644555