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Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

12 Jul 2017

Abstract excerpt

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations...

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PMID: 28699890
DOI: 10.7554/elife.24662

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