Article

The Early Pregnancy Human Placenta Shares Hypomethylation Patterns Characteristic of Solid Tumors

2017-01-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues, promote angiogenesis, while surviving hypoxia, and escape the immune system. Similarities in DNA methylation patterns between the placenta and cancers suggest that common epigenetic mechanisms...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f16130b3-a5ed-5f9b-954b-c4a8d4eaa3ce
DOI: 10.1101/098616

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Early Pregnancy Human Placenta Shares Hypomethylation Patterns Characteristic of Solid TumorsDOI 10.1101/098616Read

Recent progress towards understanding the role of DNA methylation in human placental developmentSemantic proximity Read

A complex association between DNA methylation and gene expression in human placenta at first and third trimestersSemantic proximity Read

Placental pseudo-malignancy from a DNA methylation perspective: unanswered questions and future directionsSemantic proximity Read

Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placentaSemantic proximity Read

Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcomeSemantic proximity Read

Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian PlacentasSemantic proximity Read

Regionally distinct trophoblast regulate barrier function and invasion in the human placentaSemantic proximity Read

Distinctive aspects of the placental epigenome and theories as to how they ariseSemantic proximity Read

Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblastsSemantic proximity Read

DNA Methylation Profiling Highlights the Unique Nature Of the Human Placental EpigenomeSemantic proximity Read

Distinct Patterns of Gene-Specific Methylation in Mammalian Placentas: Implications for Placental Evolution and FunctionSemantic proximity Read

Elsevier Trophoblast Research Award Lecture: Origin, evolution and future of placenta miRNAsSemantic proximity Read