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Distinctive aspects of the placental epigenome and theories as to how they arise

26 Oct 2022

Abstract excerpt

The placenta has a methylome dramatically unlike that of any somatic cell type. Among other distinctions, it features low global DNA methylation, extensive "partially methylated domains" packed in dense heterochromatin and methylation of hundreds of CpG islands important in somatic development. These features attract interest in part because a substantial fraction of human cancers feature the exact same...

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PMID: 36287261
DOI: 10.1007/s00018-022-04568-9

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