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Article

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism.

Stem cell reports - 8 Jun 2021

Okarmus Justyna, Havelund Jesper F, Ryding Matias, Schmidt Sissel I, Bogetofte Helle, Heon-Roberts Rachel, Wade-Martins Richard, Cowley Sally A, Ryan Brent J, Færgeman Nils J, Hyttel Poul, Meyer Morten

Abstract excerpt

PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic human induced pluripotent stem cells (iPSCs) with and without PARK2 knockout (KO) to investigate the effect of parkin...

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Identifiers

PMID: 34048689
DOI: 10.1016/j.stemcr.2021.04.022
PMCID: PMC8190670

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