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Article

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.

Genes & development - 15 Jul 1995

Hollingsworth N M, Ponte L, Halsey C

Abstract excerpt

Using a screen designed to identify yeast mutants specifically defective in recombination between homologous chromosomes during meiosis, we have obtained new alleles of the meiosis-specific genes, HOP1, RED1, and MEK1. In addition, the screen identified a novel gene designated MSH5 (MutS Homolog 5). Although Msh5p exhibits strong homology to the MutS family of proteins, it is not involved in DNA mismatch repair....

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Source

Identifiers

PMID: 7622037
DOI: 10.1101/gad.9.14.1728

Genes

MSH5
MSH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.PMID 7622037Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.Semantic proximity Read ↗

Caenorhabditis elegans msh-5 Is Required for Both Normal and Radiation-Induced Meiotic Crossing Over but Not for Completion of MeiosisSemantic proximity Read ↗

Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair.Semantic proximity Read ↗

A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Semantic proximity Read ↗

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Arabidopsis MutS homolog AtMSH4 functions at an early step in recombination: evidence for two classes of recombination in Arabidopsis.Semantic proximity Read ↗

MSH4 acts in conjunction with MLH1 during mammalian meiosisSemantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in Arabidopsis thaliana, but is not required for synapsis.Semantic proximity Read ↗

mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.Semantic proximity Read ↗

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