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Article

Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.

Molecular immunology - 1 Mar 2014

Yamamoto Takahiro, Tsutsumi Naotaka, Tochio Hidehito, Ohnishi Hidenori, Kubota Kazuo, Kato Zenichiro, Shirakawa Masahiro, Kondo Naomi

Abstract excerpt

Human interleukin-1 receptor-associated kinase 4 (IRAK4) deficiency and myeloid differentiating factor 88 (MyD88) deficiency syndromes are two primary immune-deficiency disorders with innate immune defects. Although new genetic variations of IRAK4 and MyD88 have recently been deposited in the single nucleotide polymorphism (SNP) database, the clinical significance of these variants has not yet been established....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24316379
DOI: 10.1016/j.molimm.2013.11.008

Genes

IRAK4

Variants

Provenance

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