Article

Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial Hypertension

2024-09-22

Abstract excerpt

<h4>Rationale</h4> Approximately 80% of patients with non-familial pulmonary arterial hypertension (PAH) lack identifiable pathogenic genetic variants. While most genetic studies of PAH have focused on predicted loss-of-function variants, recent approaches have identified ultra-rare missense variants associated with the disease. FOXF1 encodes a highly conserved transcription factor, essential for angiogenesis an...

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Literature Corpus work: 179eebc3-7f4f-5233-93f3-2f05c1052439
DOI: 10.1101/2024.09.18.611448

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