Broad functional profiling of fission yeast proteins using phenomics and machine learning

Abstract excerpt

Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe for broad cues on protein functions. We assayed colony-growth phenotypes to measure the fitness of deletion mutants for 3509 non-essential genes in 131 conditions with different nutrients, drugs, and stresses. These anal...

Topics

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• Amino Acids
• Bioinformatics and Genomic Networks
• Machine Learning
• Microbial Metabolic Engineering and Bioproduction
• Phenomics
• Phenotype
• Schizosaccharomyces
• Schizosaccharomyces pombe Proteins

Identifiers and source

Literature Corpus work

f0c685ee-8c4d-5a20-b6e1-1e31829cfbd1

DOI

10.1101/2023.04.05.535764