Article
Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
G3 (Bethesda, Md.) - 13 Oct 2016
Guo Lan, Ganguly Abantika, Sun Lingling, Suo Fang, Du Li-Lin, Russell Paul
Abstract excerpt
Heavy metals and metalloids such as cadmium [Cd(II)] and arsenic [As(III)] are widespread environmental toxicants responsible for multiple adverse health effects in humans. However, the molecular mechanisms underlying metal-induced cytotoxicity and carcinogenesis, as well as the detoxification and tolerance pathways, are incompletely understood. Here, we use global fitness profiling by barcode sequencing to...
Read the complete abstract on PubMedTopics
- Adaptation, Biological
- Arsenic
- Biological Transport
- Cadmium
- Cluster Analysis
- Computational Biology
- Cysteine