Article
Hidden in plain sight: what remains to be discovered in the eukaryotic proteome?
1 Feb 2019
Abstract excerpt
The first decade of genome sequencing stimulated an explosion in the characterization of unknown proteins. More recently, the pace of functional discovery has slowed, leaving around 20% of the proteins even in well-studied model organisms without informative descriptions of their biological roles. Remarkably, many uncharacterized proteins are conserved from yeasts to human, suggesting that they contribute to...
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