Article

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

2023-02-20

Abstract excerpt

Mutagenic antiviral drugs have shown promising results against multiple viruses, yet concerns have been raised about whether their use might promote the emergence of new and harmful viral variants. Here, we examine the genetic consequences of effective and suboptimal dosing of favipiravir and molnupiravir in the treatment of SARS-CoV-2 infection in a hamster model. We identify a dose-dependent effect upon the muta...

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Literature Corpus work: 56589c5a-ad8a-5ff2-bfe3-42abca640502
DOI: 10.1101/2023.02.20.529243

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