Article

IL-6R Protective Variant rs7529229 Reduces Interleukin-6 Signaling and Contributes To A Decreased Ischemic Stroke Risk

2020-10-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Interleukin-6 (IL-6) signaling is associated with an increased risk of coronary artery disease (CAD) and ischemic stroke (IS). Growing evidence shows that the minor alleles of IL-6 receptor gene (<italic>IL-6R)</italic> variants rs2228145, rs7529229, and rs4129267<italic> </italic>significantly increase soluble IL-6R levels and reduce CAD risk. However, the role...

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Literature Corpus work: f07a4c6c-c597-5b60-b65c-0f34f69dcf9a
DOI: 10.21203/rs.3.rs-93821/v1

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