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Article

Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.

Annals of neurology - 1 Nov 2015

Lim Youngshin, Cho Il-Taeg, Schoel Leah J, Cho Ginam, Golden Jeffrey A

Abstract excerpt

OBJECTIVE: Mutations in receptor expression enhancing protein 1 (REEP1) are associated with hereditary spastic paraplegias (HSPs). Although axonal degeneration is thought to be a predominant feature in HSP, the role of REEP1 mutations in degeneration is largely unknown. Previous studies have implicated a role for REEP1 in the endoplasmic reticulum (ER), whereas others localized REEP1 with mitochondria. We sought...

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Source

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Identifiers

PMID: 26201691
DOI: 10.1002/ana.24488
PMCID: PMC4681538

Genes

REEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts.PMID 26201691Read ↗

Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31.Semantic proximity Read ↗

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A complete overview of REEP1: old and new insights on its role in hereditary spastic paraplegia and neurodegeneration.Semantic proximity Read ↗

Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.Semantic proximity Read ↗

Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology.Semantic proximity Read ↗

REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31.Semantic proximity Read ↗

Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia.Semantic proximity Read ↗

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