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Autophagy across tissues of aging mice

4 Jun 2025

Abstract excerpt

Autophagy is a 'waste-disposal' pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during aging remain unknown. Here, we present the most comprehensive in vivo study of autophagic flux to date. We employed transgenic mice overexpressing tandem-florescent LC3B (RFP-GFP-LC3B) to measure autophagic flux in...

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PMID: 40465797
DOI: 10.1371/journal.pone.0325505

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