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Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging

5 Feb 2025

Abstract excerpt

Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation, has been reported in various organs and cells from rodents and humans. Disruption of CMA recapitulates features of aging, whereas activating CMA in mice protects against...

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PMID: 39910244
DOI: 10.1038/s43587-024-00799-6

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