Back to search

Article

F3 expression drives sensitivity to the antibody-drug conjugate tisotumab vedotin in glioblastoma

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>Purpose The gene <italic>F3</italic>, encoding Tissue Factor (TF), is expressed in many cancers and contributes to their malignancy. Among adult-type diffuse gliomas, IDH wild-type (IDH<sup>wt</sup>) glioblastomas (GBM) express more TF than IDH mutant (IDH<sup>mut</sup>) gliomas. Tisotumab vedotin (TisVed), an anti-TF antibody conjugated to monomethyl auristatin E, is a therapeutic des...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f03d3b3a-9677-5cf0-a396-adfdd9d654e0
DOI
10.21203/rs.3.rs-5397657/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
F3 expression drives sensitivity to the antibody-drug conjugate tisotumab vedotin in glioblastomaDOI 10.21203/rs.3.rs-5397657/v1
A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsSemantic proximity
Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant GliomasSemantic proximity
Management of Asynchronous Multifocal Adult Glioblastoma with Loss of BRAFV600E-Mutant Clonality: A Case ReportSemantic proximity
Inhibition of HVEM suppresses growth and invasion of mesenchymal glioblastomaSemantic proximity
YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma.Semantic proximity
Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastomaSemantic proximity
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodelingSemantic proximity
Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with GliomaSemantic proximity
Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient SurvivalSemantic proximity
Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escapeSemantic proximity
High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic IsoformsSemantic proximity
Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: a case report.Semantic proximity
Select a neighboring publication to make it the new centre.