Article

Mechanical stimulation regulates differentiation of bone marrow stem cells by modulating miR-140-5p via TGFβ1/Smad2 signaling pathway

2020-02-13

Abstract excerpt

<title>Abstract</title> <p>Background: Osteoporosis is a common progressive bone disease that drastically impairs patient health, independent mobility, and quality of life, and there is an urgent need for improved preventive and therapeutic strategies. A shift in bone marrow mesenchymal stem cell (BMSC) differentiation from osteogenic to adipogenic may contribute to disease pathogenesis. Mechanical stress on BMSC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dcd859e0-39ae-59b5-8ac7-e7cb16168c2a
DOI: 10.21203/rs.2.23417/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanical stimulation regulates differentiation of bone marrow stem cells by modulating miR-140-5p via TGFβ1/Smad2 signaling pathwayDOI 10.21203/rs.2.23417/v1Read

Tension force stress downregulates the expression of osteogenic markers and mineralization in embryonic stem cell-derived embryoid bodiesSemantic proximity Read

Osteocyte-Mediated Translation of Mechanical Stimuli to Cellular Signaling and Its Role in Bone and Non-bone-Related Clinical ComplicationsSemantic proximity Read

Mechanotransduction in Mesenchymal Stem Cells (MSCs) Differentiation: A ReviewSemantic proximity Read

Osteoblast Differentiation at a GlanceSemantic proximity Read

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read

Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissuesSemantic proximity Read

Mechanical Force-Induced Specific MicroRNA Expression in Human Periodontal Ligament Stem CellsSemantic proximity Read

Interaction of material stiffness and negative pressure to enhance differentiation of bone marrow-derived stem cells and osteoblast proliferation.Semantic proximity Read

Orchestrating osteogenic differentiation of mesenchymal stem cells—identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic roleSemantic proximity Read

An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem CellsSemantic proximity Read

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cellsSemantic proximity Read