Macropinocytosis inhibition attenuates pro-fibrotic responses in lung fibroblasts and pulmonary fibrosis

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disorder with limited treatment options. Macropinocytosis is one of the key cellular processes involved in nutrient consumption from the extracellular environment under stress conditions. Here, we studied the role of macropinocytosis in lung fibroblast activation and experimental pulmonary fibrosis. We found that macropinocytosis...

Topics

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• Antibiotics, Antineoplastic
• Autophagy
• Bleomycin
• Idiopathic Pulmonary Fibrosis
• NF-kappa B
• Primary Cell Culture
• Proto-Oncogene Proteins c-akt
• TOR Serine-Threonine Kinases

Identifiers and source

Literature Corpus work

f03140a7-00f6-5bd2-bbb6-4fac19ada50c

DOI

10.1101/2025.07.09.663937