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The associations of APP, PSEN1, and PSEN2 genes with Alzheimer's disease: A large case-control study in Chinese population.

CNS neuroscience & therapeutics - 1 Jan 2023

Xiao Xuewen, Liu Hui, Zhou Lu, Liu Xixi, Xu Tianyan, Zhu Yuan, Yang Qijie, Hao Xiaoli, Liu Yingzi, Zhang Weiwei, Zhou Yafang, Wang Junling, Li Jinchen, Jiao Bin, Shen Lu, Liao Xinxin

Abstract excerpt

AIM: The associations of non-pathogenic variants of APP, PSEN1, and PSEN2 with Alzheimer's disease (AD) remain unclear. This study is aimed at determining the role of these variants in AD. METHODS: Our study recruited 1154 AD patients and 2403 controls. APP, PSEN1, PSEN2, and APOE were sequenced using a targeted panel. Variants were classified into common or rare variants with the minor allele frequencies (MAF)...

Topics

Humans
Alzheimer Disease
Amyloid beta-Protein Precursor
Case-Control Studies
East Asian People
Mutation
Presenilin-1
Presenilin-2

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36217304
DOI: 10.1111/cns.13987
PMCID: PMC9804049

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