Article

Frequency of Variants in Mendelian Alzheimer’s Disease Genes within the Alzheimer’s Disease Sequencing Project (ADSP)

2023-10-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Prior studies using the ADSP data examined variants within presenilin-2 ( PSEN2 ), presenilin-1 ( PSEN1 ), and amyloid precursor protein ( APP ) genes. However, previously-reported clinically-relevant variants and other predicted damaging missense (DM) variants have not been characterized in a newer release of the Alzheimer’s Disease Sequencing Project (ADSP). <h4>Objective</h...

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Literature Corpus work: 027e8dfa-8f2e-57f5-b649-563e6727aae4
DOI: 10.1101/2023.10.24.23297227

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