Article
Screening for Genetic Mutations Associated with Early-Onset Alzheimer's Disease in Han Chinese.
Current Alzheimer research - 1 Jan 2022
Liu Cuicui, Cong Lin, Zhu Min, Wang Yongxiang, Tang Shi, Han Xiaojuan, Zhang Qinghua, Tian Na, Liu Keke, Liang Xiaoyan, Fa Wenxin, Wang Nan, Hou Tingting, Du Yifeng
Abstract excerpt
BACKGROUND: Early-onset Alzheimer's disease (EOAD) is highly influenced by genetic factors. Numerous mutations in amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been identified for EOAD, but they can only account for a small proportion of EOAD cases. OBJECTIVE: This study aimed to screen genetic mutations and variants associated with EOAD among Han Chinese adults. METHODS: This...
Topics
- Adult
- Humans
- Alzheimer Disease
- East Asian People
- Mutation
- Amyloid beta-Protein Precursor
- Mutation, Missense
- Presenilin-2
- Presenilin-1