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Article

Association of rare variants in neurodegenerative genes with familial Alzheimer's disease.

Annals of clinical and translational neurology - 1 Oct 2020

Zhang Weiwei, Jiao Bin, Xiao Tingting, Liu Xixi, Liao Xinxin, Xiao Xuewen, Guo Lina, Yuan Zhenhua, Yan Xinxiang, Tang Beisha, Shen Lu

Abstract excerpt

OBJECTIVE: To investigate the impact of rare variants underlying neurodegenerative-related genes to familial Alzheimer's disease (AD). METHODS: We performed targeted sequencing of 277 neurodegenerative-related genes on probands from 75 Chinese AD families non-carrying causative mutation of dementia genes. Rare coding variants segregated in families were tested for association in an independent cohort of 506...

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Identifiers

PMID: 32941707
DOI: 10.1002/acn3.51197
PMCID: PMC7545599

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