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Alanine scanning mutagenesis of the MEDI4839 (Suvratoxumab) epitope reduces alpha toxin lytic activity <i>in vitro</i> and <i>S. aureus</i> fitness in infection models

2018-05-16

Abstract excerpt

Alpha toxin (AT) is a cytolytic pore-forming toxin that plays a key role in Staphylococcus aureus pathogenesis, consequently extensive research was undertaken to understand the AT mechanism of action and its utility as a target for novel prophylaxis and treatment strategies against S. aureus infections. MEDI4893 (Suvratoxumab) is a human anti-AT IgG1 monoclonal antibody (mAb), which targets AT and is currently i...

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Literature Corpus work
ef8abd76-8ea5-500f-b98d-535c80d2bd5d
DOI
10.1101/323642
Open publication

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Alanine scanning mutagenesis of the MEDI4839 (Suvratoxumab) epitope reduces alpha toxin lytic activity <i>in vitro</i> and <i>S. aureus</i> fitness in infection modelsDOI 10.1101/323642
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