Article
Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.
Antimicrobial agents and chemotherapy - 1 Sept 2016
Tabor David E, Yu Li, Mok Hoyin, Tkaczyk Christine, Sellman Bret R, Wu Yuling, Oganesyan Vaheh, Slidel Tim, Jafri Hasan, McCarthy Michael, Bradford Patricia, Esser Mark T
Abstract excerpt
Staphylococcus aureus infections lead to an array of illnesses ranging from mild skin infections to serious diseases, such endocarditis, osteomyelitis, and pneumonia. Alpha-toxin (Hla) is a pore-forming toxin, encoded by the hla gene, that is thought to play a key role in S. aureus pathogenesis. A monoclonal antibody targeting Hla, MEDI4893, is in clinical development for the prevention of S. aureus...
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