Article

A Protein A based <i>Staphylococcus aureus</i> vaccine with improved safety

2021-02-19

Abstract excerpt

Exposure to Staphylococcus aureus does not lead to immunity as evidenced by the persistent colonization of one third of the human population. S. aureus immune escape is mediated by factors that preempt complement activation, destroy phagocytes, and modify B and T cell responses. One such factor, Staphylococcal protein A (SpA) encompasses five Immunoglobulin binding domains (IgBDs) that associate with the Fcγ dom...

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Literature Corpus work: dc765e4e-62cb-57cb-87df-ebbbbf51d735
DOI: 10.1101/2021.02.19.432007

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