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Article

Unlatching of the stem domains in the Staphylococcus aureus pore-forming leukocidin LukAB influences toxin oligomerization.

The Journal of biological chemistry - 1 Dec 2023

Ilmain Juliana K, Perelman Sofya S, Panepinto Maria C, Irnov Irnov, Coudray Nicolas, Samhadaneh Nora, Pironti Alejandro, Ueberheide Beatrix, Ekiert Damian C, Bhabha Gira, Torres Victor J

Abstract excerpt

Staphylococcus aureus (S. aureus) is a serious global pathogen that causes a diverse range of invasive diseases. S. aureus utilizes a family of pore-forming toxins, known as bi-component leukocidins, to evade the host immune response and promote infection. Among these is LukAB (leukocidin A/leukocidin B), a toxin that assembles into an octameric β-barrel pore in the target cell membrane, resulting in host cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37802313
DOI: 10.1016/j.jbc.2023.105321
PMCID: PMC10665946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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