Article

A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 Diabetes

2020-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is development of autoantibodies and T-cells directed at an epitope in the B-chain of insulin (insB:9-23). Analysis of microbial protein sequences with homology to insB:9-23 sequence revealed 17 peptides showing >50% identity to insB:9-23. Of these, o...

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Literature Corpus work: ef7b7aa4-51d0-55ad-9ae4-31ea85c727b6
DOI: 10.1101/2020.10.22.350801

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