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Pathophysiology of Type 1 Diabetes and Gut Microbiota Role

24 Nov 2022

Abstract excerpt

Type 1 diabetes (T1D) is a multifactorial autoimmune disease driven by T-cells against the insulin-producing islet β-cells, resulting in a marked loss of β-cell mass and function. Although a genetic predisposal increases susceptibility, the role of epigenetic and environmental factors seems to be much more significant. A dysbiotic gut microbial profile has been associated with T1D patients. Moreover, new evidence...

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PMID: 36498975
DOI: 10.3390/ijms232314650

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