Article

High expression of LncRNA HOTAIR is a risk factor for temozolomide resistance in glioblastoma via activation of the miR-214/β-catenin/MGMT pathway

2024-07-29

Abstract excerpt

<title>Abstract</title> <p>Backgroud: HOX transcript antisense RNA (HOTAIR) is upregulated in glioblastoma (GBM) and associated with temozolomide (TMZ) resistance. However, the mechanisms underlying HOTAIR-mediated TMZ resistance remains poorly understood. Methods HOTAIR expression in glioma-related public datasets and drug response estimation were analyzed using bioinformatics. These findings were verified by...

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Literature Corpus work: ef743f61-dac7-58f7-ba13-738067f5d87e
DOI: 10.21203/rs.3.rs-4674700/v1

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