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Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes

29 Sept 2020

Abstract excerpt

BACKGROUND: Gliomas evade current therapies through primary and acquired resistance and the effect of temozolomide is mainly restricted to methylguanin-O6-methyltransferase promoter (MGMT) promoter hypermethylated tumors. Further resistance markers are largely unknown and would help for better stratification. METHODS: Clinical data and methylation profiles from the NOA-08 (104, elderly glioblastoma) and the EORTC...

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PMID: 32991787
DOI: 10.1002/cam4.3447

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