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Identifying Predictive Gene Expression and Signature Related to Temozolomide Sensitivity of Glioblastomas

22 May 2020

Abstract excerpt

Temozolomide (TMZ) is considered a standard chemotherapeutic agent for glioblastoma (GBM). Characterizing the biological molecules and signaling pathways involved in TMZ sensitivity would be helpful for selecting therapeutic schemes and evaluating prognosis for GBM. Thus, in the present study, we selected 34 glioma cell lines paired with specific IC50 values of TMZ obtained from Cancerrxgene and RNA-seq data...

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PMID: 32528873
DOI: 10.3389/fonc.2020.00669

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