Article
The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma.
Cell death & disease - 28 Sept 2021
Ahmadov Ulvi, Picard Daniel, Bartl Jasmin, Silginer Manuela, Trajkovic-Arsic Marija, Qin Nan, Blümel Lena, Wolter Marietta, Lim Jonathan K M, Pauck David, Winkelkotte Alina Marie, Melcher Marlen, Langini Maike, Marquardt Viktoria, Sander Felix, Stefanski Anja, Steltgens Sascha, Hassiepen Christina, Kaufhold Anna, Meyer Frauke-Dorothee, Seibt Annette, Kleinesudeik Lara, Hain Anika, Münk Carsten, Knobbe-Thomsen Christiane Brigitte, Schramm Alexander, Fischer Ute, Leprivier Gabriel, Stühler Kai, Fulda Simone, Siveke Jens T, Distelmaier Felix, Borkhardt Arndt, Weller Michael, Roth Patrick, Reifenberger Guido, Remke Marc
Abstract excerpt
Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. Long non-coding RNAs (lncRNAs) have been shown to contribute to glioblastoma pathogenesis and could potentially serve as novel biomarkers. The clinical significance of...
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