Article

Chemical-induced degradation of PreS2 mutant surface antigen reverses HBV-mediated hepatocarcinogenesis

2022-01-24

Abstract excerpt

Naturally evolved immune-escape PreS2 mutant is an oncogenic caveat of liver cirrhosis and hepatocellular carcinoma (HCC) during chronic hepatitis B virus (HBV) infection. Notably, PreS2 mutants is prevalent in above 50% of patients with HCC. Intrahepatic expression of PreS2 mutant large surface antigen (PreS2-LHBS) induces endoplasmic reticulum stress, mitochondria dysfunction, cytokinesis failure and subsequent...

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Literature Corpus work: ef5c168f-e731-570c-a6ea-e907294ba2e8
DOI: 10.1101/2022.01.24.477454

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