Back to search

Article

Engineered Exosomes for the Targeted Delivery of A Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.

2022-01-28

Abstract excerpt

<h4>Background: </h4> Sorafenib is one of the few effective first-line drugs approved for the treatment of advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common among individuals with HCC. Thus, there is an urgent need to solve this problem. Results Recent evidence indicated that the anticancer activity of sorafenib mainly relies on the induction of ferroptosis. In our stu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b95592d6-1404-53e5-af06-ff6571ab44b8
DOI
10.21203/rs.3.rs-1108956/v2
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Engineered Exosomes for the Targeted Delivery of A Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.DOI 10.21203/rs.3.rs-1108956/v2
MicroRNA-140-5p Suppresses The PD-L1 Level In Exosomes Derived From Hepatocellular Carcinoma Cells, Thereby Attenuating The Chemoresistance, Autophagy And Stemness Induced By Sorafenib In Hepatocellular CarcinomaSemantic proximity
Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1Semantic proximity
EZH2 Suppresses Ferroptosis in Hepatocellular Carcinoma and Reduces Sorafenib Sensitivity Through Epigenetic Regulation of TFR2Semantic proximity
5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosisSemantic proximity
CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinomaSemantic proximity
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinomaSemantic proximity
In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signalingSemantic proximity
Combination therapy based on dual-target biomimetic nano-delivery system for overcoming cisplatin resistance in hepatocellular carcinomaSemantic proximity
RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancerSemantic proximity
Modulating G6PD/PGD to overcome FSP1/DHODH‐mediated ferroptosis defence: A novel oridonin derivative suppresses liver cancerSemantic proximity
Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistanceSemantic proximity
RNA nanotherapeutics for hepatocellular carcinoma treatmentSemantic proximity
Select a neighboring publication to make it the new centre.