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Article

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability.

Oncotarget - 26 Apr 2016

Yen Tim Ting-Chung, Yang Anderson, Chiu Wen-Tai, Li Tian-Neng, Wang Lyu-Han, Wu Yi-Hsuan, Wang Hui-Chen, Chen Linyi, Wang Wen-Ching, Huang Wenya, Chang Chien-Wen, Chang Margaret Dah-Tsyr, Shen Meng-Ru, Su Ih-Jen, Wang Lily Hui-Ching

Abstract excerpt

Hepatitis B virus (HBV) is a driver of hepatocellular carcinoma, and two viral products, X and large surface antigen (LHBS), are viral oncoproteins. During chronic viral infection, immune-escape mutants on the preS2 region of LHBS (preS2-LHBS) are gain-of-function mutations that are linked to preneoplastic ground glass hepatocytes (GGHs) and early disease onset of hepatocellular carcinoma. Here, we show that...

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Source

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Identifiers

PMID: 26992221
DOI: 10.18632/oncotarget.8109
PMCID: PMC5029631

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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