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Article

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer.

Cancer letters - 1 Dec 2017

Yagdi Efe Esma, Mazumder Aloran, Lee Jin-Young, Gaigneaux Anthoula, Radogna Flavia, Nasim Muhammad Jawad, Christov Christo, Jacob Claus, Kim Kyu-Won, Dicato Mario, Chaimbault Patrick, Cerella Claudia, Diederich Marc

Abstract excerpt

Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binders, validated by in cellulo α-tubulin degradation....

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Identifiers

PMID: 28943451
DOI: 10.1016/j.canlet.2017.09.011

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BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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